TD-12AT PLUS Transdermal Diffusion System
Product Introduction:
Wahyong TD-12AT PLUS Transdermal Diffusion system consists of a diffusion host and an automatic sampler. The TD-12 transdermal diffusion host includes two sets of 6 diffusion cells, used for diffusion experiments.The system is applied to the transdermal drug release test of ointments, plasters, paints, films, and aerosols. The transdermal absorption model is used to study the efficiency of drug penetration through the skin. The specific technical features are as follows：
1. Compliant with regulatory requirements
The instrument Complies with the requirements described in USP<1724> and the Technical Guidelines for Pharmaceutical Study of Transdermal Patches for Chemical Generic Drugs. It is a reliable and reproducible method for determining the release of semi-solid dosage forms, and is currently the most commonly used method.
2. Franz-diffusion cell
Franz-diffusion cell is a vertical diffusion cell, mainly composed of glass receptor chamber, membrane placement chamber, osmosis membrane, membrane cover, transparent anti evaporation cover, etc.The bottom of the glass receptor chamber is equipped with an inlet/outlet hole, and the upper end of the membrane placement chamber is equipped with an exhaust hole.
Wahyong Franz-diffusion cell
3. Temperature monitoring system
①The diffusion cell adopts a dry heating method with high heating efficiency, and the temperature of the receiving and donor rooms is accurately controlled（Deviation≤±0.5℃）；
②The double insulation design of the diffusion cell anti evaporation cover and the body protective cover avoids the evaporation of solvents in the formulation during the experimental process, and also prevents the temperature of the cell and the drug from being affected by the external environment；
③Real time monitoring and recording of the temperature of the dry heating module and the receiving pool medium, and generating temperature curves；
④Each diffusion pool is equipped with an independent temperature monitoring module to monitor the temperature of the medium inside the diffusion pool, ensuring the accuracy of the temperature of the receptor media；
⑤Same temperature rehydration design to avoid the impact of temperature fluctuations on in vitro release or permeation during rehydration.
4. Selection of Franz-diffusion cell
①Material: Improved Franz-diffusion cell, made of glass material with good heat transfer performance, fixed release area of 1.77cm2（φ=15mm）；
②Quantitative administration: equipped with quantitative rings of different thicknesses (1mm/2mm/3mm) to flexibly control different dosages of administration；
③Variable volume of diffusion cell: By selecting different volumes of agitators, the volume of diffusion pool can be flexibly changed to meet different experiment；
④Adaptive clamping device: spring+knob design, adaptive clamping and adjustment of the gap between the receiving cell and the donor room.
5. Automatic exhaust
①Automatic exhaust design ensures complete contact between the skin or lower surface of the osmosis membrane and the receiving liquid throughout the entire experimental process；
②The Franz-diffusion cell automatically tilts as a whole, and the bubbles are discharged from the upper exhaust port.
6. Automatic sampling
①Automatic sampling design, which allows for the entry and extraction of media from the bottom of the diffusion cell, enabling full and partial sampling；
②The same machine can perform penetration testing on 12 samples simultaneously, with two sets of 6+6 (reference + self developed) for the upper and lower parts, and different temperatures and stirring speeds can be set.
7. The flow path is concise and clear
①Excellent flow path design, automatic lubrication of pipelines before sampling, and automatic emptying of pipelines after sampling to avoid cross contamination of samples；
②12 diffusion cells are independent media channels that can simultaneously conduct 12 sets of media release experiments；
③After the experiment, the diffusion cell and pipeline system can be automatically cleaned and emptied；
④Optional Wahyong online media degasser for degassing the released media.
Flow path diagram
8. Accurate sampling
①High precision imported injection pump can achieve fast and accurate sampling, with a sampling deviation of≤0.1ml；
②The sampler is compatible with large test tubes (10ml) and liquid phase small bottles for sampling, with 39 sampling points.
High precision imported injection pump
9. Verification System
After the instrument is installed in place, Wahyong after-sales engineers will conduct comprehensive verification of the instrument's hardware and software.
Provide professional 3Q verification services (IQ, OQ, PQ).
